The David procedure after the Ross operation: case series

In patients with severe aortic valve (AV) pathology, its replacement is a method of surgical treatment [1][2]. Various types of prosthetic aortic valves have been proposed, including a pulmonary autograft (Ross operation) [3]. The pulmonary autograft in the aortic position provides high survival rate and quality of life, a minimal rate of valverelated complications, and excellent hemodynamic characteristics both in the early and long term [4-8]. However, in some patients in the long-term period after the Ross operation, pulmonary autograft dilatation may occur, which, in turn, is one of the reasons for resurgery [9-14]. In patients who require surgery for annuloaortic ectasia with AV regurgitation or aortic root aneurysm (or both) with normal AV leaflets, David procedure is considered [15]. In this article, we report four cases of David procedures being performed after the prior Ross operation.

Material and methods

Patients after the Ross operation. In our center, from April 2009 to December 2020, 212 Ross operations were performed on patients aged 18 years and older. The median age of patients was 34 (27-45) years. The main indication for surgery was severe aortic stenosis in 124 (58%) subjects, while severe aortic regurgitation in 88 (42%). Infective endocarditis was in 55 (26%) patients. Bicuspid AV was diagnosed in 131 (62%) patients. During the Ross operation, 14 (2,2%) patients underwent surgery on the ascending aorta. In all patients, pulmonary autograft was implanted using the full root replacement technique, and 54 (25%) patients underwent a modified Ross operation (Table 1).

Table 1

Initial demographic characteristics of patients at the time of the Ross operation

Abbreviation: AV — aortic valve.

Study population. In the long-term period, 10 (4,7%) patients required reoperation on the AV and 7 (3,3%) of them required another intervention on the ascending aorta due to aortic dilatation. Four out of 10 patients underwent David procedure. The age of patients was from 23 to 45 years. Three patients had prior hypertension. The follow-up duration from the Ross operation to the David procedure ranged from 26 to 140 months. All patients underwent transthoracic and transesophageal echocardiography (Figure 1), contrast-enhanced aortic computed tomography (Figure 2), while patients over 35 years of age underwent coronary angiography.

Figure 1. Intraoperative transesophageal echocardiography.
Note: dilatation of the sinuses of Valsalva and the proximal ascending aorta.

Figure 2. Contrast-enhanced aortic computed tomography.
Note: dilatation of the sinuses of Valsalva and the proximal ascending aorta.

Surgical technique. All reoperations were performed through median sternotomy. After cardiolysis, normothermic cardiopulmonary bypass was instituted. The left heart was drained through the right upper pulmonary vein. The aorta was cannulated as distally as possible, closer to the aortic arch. For cardioplegia, Custodiol at a dose of 2000 ml was used. Cardioplegic solution was delivered after transverse aortotomy, antegrade through the coronary artery orifices. The aortic root was maximally mobilized. From the left ventricular outflow tract, 9 to 12 sutures were placed (Ethibond 2/0”). A synthetic vascular prosthesis was implanted into the aortic root. The commissures and the remaining annulus part were sutured with a continuous suture using the Premilene 3/0-4/0 thread to the inner prosthesis wall. In the projection of the left and right coronary cusps, two holes were cut out on the prosthesis, and the coronary arteries orifices were implanted in them with a continuous suture (Premilene 6/0). The distal prosthesis anastomosis was formed with the ascending aorta in an end-to-end manner with a continuous suture (Premilene 4/0).


All patients had AV annulus dilatation from 27 to 30 mm (Table 2). The duration of myocardial ischemia and cardiopulmonary bypass ranged from 87 to 142 minutes and from 119 to 165 minutes, respectively. The vascular prosthesis diameter was 30 mm in two patients and 32 mm in the remaining ones. The length of stay in the intensive care unit ranged from 16 to 23 hours (Tables 3-5). In the early postoperative period, none of the patients had following postoperative complications: acute renal failure requiring hemodialysis, perioperative myocardial injury, stroke, sternal infection, respiratory failure requiring mechanical ventilation ?24 h, resternotomy due to bleeding and tamponade, and inhospital death. At the time of discharge, there were no aortic regurgitation in all patients. The follow-up period for patients after David’s operation ranged from 2 to 84 months. All patients are alive, and there were no reoperations. In one patient, a slight aortic regurgitation developed in the long-term period, while in three there was no regurgitation.

Table 2

Characteristics of patients at the time of the David procedure

Table 3

Intraoperative parameters

Table 4

Postoperative parameters

Table 5

Postoperative echocardiographic parameters

Abbreviations: AV — aortic valve, AR — aortic regurgitation.


The Ross operation has been proposed in AV surgery as a procedure that provides excellent hemodynamic parameters and freedom from anticoagulants [3][16][17]. One of its disadvantages is neoaortic root dilatation, which can lead to AV insufficiency and aortic wall dissection [14][18][19].

The main idea of this work was to show the potential of repeated valve-sparing surgery after the Ross operation in case of AV insufficiency and aortic dilation.

Isolated cases of David or Yacoub valve-sparing surgery after the Ross operation have been published in the literature [20-27]. Liebrich M, et al. published 18 cases of the David procedure after the Ross operation. The average period of reoperation was 11±3,2 years. The average age of operated patients was 49,8±13,9 years, mostly men (83%). There was no inhospital and 30-day mortality after the David procedure. During the follow-up period, one patient after 2,6 years required a second valve replacement surgery due to aortic regurgitation recurrence. Thus, the authors concluded that David procedure is possible after the Ross procedure with a low rate of mortality and postoperative complications [27].

In our opinion, one of the unresolved issues is the question of what neoaortic diameter should be operated on in such patients. In our practice, we focus on modern European guidelines for the diagnosis and treatment of aortic pathology [28]. Without significant aortic regurgitation, we perform surgical intervention with a diameter of 55 mm, while with significant aortic regurgitation — with a neoaortic diameter of 45 mm. A number of authors have described cases of Type A aortic dissection after the Ross operation [29][31]. Recently, Kalogerakos PD, et al. [32] concluded that aortic root dilatation is more unfavorable than mid-ascending aortic dilatation. According to this study, surgery should be considered when the diameter of aortic root and mid-ascending aorta is from 50 mm and 52,5 mm, respectively.

Several studies have confirmed that preoperative aortic regurgitation and morphological bicuspid AV are independent risk factors leading to neoaortic dilatation [16][20]. Based on this, as a prevention of aortic root dilatation, in our clinic, starting from 2014, all patients received modified Ross operation using a Dacron prosthetic vascular [21]. We also published the mid-term outcomes of this modification [33].


Progressive neosinus dilatation is one of the complications after Ross surgery. The presented case series show that David procedure can be performed safely and effectively in a significant number of patients requiring a second autograft surgery due to neosinus dilatation. In the medium term, the David procedure has shown good outcomes in these patients with 100% survival and no aortic regurgitation and reoperation.

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